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Cancer Cell , 11 (6), 526538

V.RobisonA

Insights of mitochondrial involvement in alcoholic fatty liver disease

Abstract Pesticide use is inseparable part of food production

Interestingly, DHODH and GPX4 constitute two primary defenses to detoxify lipid peroxidation in the mitochondria, and inhibiting one pathway can enforce cell more partial to the other one, whereas inactivation of both can lead to ferroptosis triggered by mitochondrial lipid peroxidation (Mao et al., 2021)