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The FDA has released a series of documents since 2017 detailing how RWE may be used in submissions for medical devices, drugs, and biologics, including its 2018 Framework for Real-World Evidence and more recent guidance on data standards and the evaluation of electronic health record and claims data

doi:10.1038/ejcn.2012.126 Ahn HY, Kim M, Chae JS, et al

[DOI] [PubMed] [Google Scholar] Jiang R, Hu FB, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Rosner BA, Willett WC

It absorbs water, tidies up leftover debris, and quietly moves things along

Just like collagen, elastin, and all the other good stuff that keeps us looking young