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An in vivo cytotoxic assay also demonstrated that overexpression of hABCB6 core confers cellular resistance to Cd(II)

The company advanced the compound through Phase 2 clinical trials in the mid-2000s

J.KullbergB

Fetal alcohol syndrome: inhibition of placental zinc transport as a potential mechanism for fetal growth retardation in the rat

Peripherally, KynA has been shown to reduce stress-induced colitis in mice by promoting NLRP3 inflammasome autophagy, demonstrating the pervasive impact of this metabolite [122]