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ASD varies in degrees of severity, occurring in 1% of the population, and its prevalence has been increasing during the last three decades ( FMR1 gene sequence on the chromosome X that results in fragile X syndrome (FXS) or fragile X-premutation tremor/ataxia syndrome (FXTAS) are among the leading genetic causes of ASD ( It has been recently proposed that a significant number of ASD cases could be associated with various metabolic abnormalities, some of them identifiable only through untargeted metabolomic profiling, simultaneously opening additional space for therapeutic attempts ( Inborn Errors of Metabolism Clinical symptoms deriving from central nervous system (CNS) occur in more than 50% of patients with inborn errors of metabolism (IEM)

Some studies in rodents have added KYNA at massive doses (well over 100 mg/kg, getting into the millimolar range in serum/plasma), seemingly without ill effects (indeed sometimes with protective effects)

However, the dynamic range for the maximum change in peak excitation ratio was significantly decreased compared to roGFP2 (see Figure 2 and Table 1)

Amphetamine has been used as an animal model of mania since 1978, and it is twice as likely to trigger psychosis than methylphenidate (Moran LV et al, N Engl J Med 2019;380(12):11281138)

PMID 20570447