Polyglutamylation of folate in cells ensures its metabolic retention and facilitates enzyme specificity [49], thereby supporting mitochondrial function and oxidative stress toleranceboth crucial for the persistence and activation of fibrogenic cells [7]
Cell 17, 46064618
In granulosa cells of women with endometriosis, elevated lipid peroxidation markers such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been observed, accompanied by decreased glutathione (GSH) and glutathione peroxidase 4 (GPx4), key inhibitors of ferroptosis ( Ferroptosis exerts a double-edged effect in endometriosis: while it damages ovarian granulosa cells, oocytes, and embryosdisrupting oocyte maturation, decreasing oocyte retrieval rates, and impairing embryonic developmentit also promotes ectopic lesion growth through downstream signaling pathways that enhance angiogenesis and inflammation ( Therapeutically, ferroptosis inducers can promote lipid ROS accumulation and endometriotic cell death but may exacerbate granulosa cell damage, while ferroptosis inhibitors protect granulosa cells against oxidative damage
These findings from the observed result suggested that the tested compounds possess dual inhibitory effect (COX-2/5-LOX) and have the potential to inhibit both lipooxygenases as well as cyclooxygenase pathways of arachidonic acid metabolites, supported by the mild anti-histaminic effect
Trn mi nn tng mng x hi, nhng sn phm kem dng glutathione ang lm ma lm gi vi hiu qu dng trng, chng oxy ha mnh m
