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In ferroptosis, SLC7A11 and GSH depletion lead to iron-dependent ROS accumulation ( Ferroptosis and alzheimers disease Iron homeostasis and alzheimers disease Regulation of iron homeostasis is important for maintaining normal brain function, and dysregulation of iron homeostasis in the brain can lead to oxidative stress and inflammatory responses, resulting in cell damage and ultimately neurodegenerative diseases

Mechanistically, plumbagin interferes with the YTHDF1-mediated m 6 A methylation pathway that regulates SLC7A5 translation (84)

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29 Early studies posited that single-stranded RNA could not form double-stranded structures

The subsequent translocation of Nrf2 into the nucleus leads to upregulation of GPX4 expression