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As to the aches and pains, breathlessness etc, this could be due to B12 needing potassium to build RBC, so I would check out low potassium symptoms and eat a banana or maybe two until you have fathomed it out

Used appropriately, Vitamin B12 can help improve energy in patients who are low or trending low-normal relative to their needs

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Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine