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1A, the loss of cell viability was partially reversed by the necrosis inhibitor Necrostatin-1 (Nec-1) and the apoptosis inhibitor Z-VAD-FMK

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The effect, however, was less pronounced at lower concentrations

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& Melton, D

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Nampt-IN-20 exerts antiproliferative effects in A2780 ovarian cancer cells

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This imbalance renders granulosa cells vulnerable to ferroptosis, which can impair estrogen synthesis and disrupt follicular development ( - expression and promoting lipid peroxidation, ultimately triggering ferroptosis ( Notably, androgen excess, a hallmark of PCOS, may also contribute to ferroptosis

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