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Genetic and morphological features of human iPSC-derived neurons with chromosome 15q11.2 (BP1-BP2) deletions

The amino acid sequence The specific sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

Examining the expression of clock proteins at 4-hour intervals over a 24-hour period and their subcellular localisation during the light (10am) and the start of the dark period (6pm), revealed that BMAL1 expression was highest during the light period (6am-2pm) ( Figure 3A ), which corresponded with the nuclear localisation of BMAL1 at 10am ( Figure 5A )

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These antibodies contribute to glandular injury via complement-dependent and antibody-dependent cell-mediated cytotoxicity, and promote the release of cytokines such as IL-6, IL-1, and IL-8, which enhance lymphocyte accumulation and the local inflammatory response