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This study demonstrates for the first time that VACV infection leads to the activation of the nuclear factor erythroid 2 (Nrf2)/antioxidant response element pathway, a key regulator of cellular antioxidant responses, a mechanism not previously described for any poxvirus

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Consequently, ARA-290 activates potent anti-inflammatory and cytoprotective pathways selectively in damaged tissue, making it a primary subject of research for Small Fiber Neuropathy (SFN), Sarcoidosis, and metabolic dysregulation

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