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It has been demonstrated that ROS-based therapy can trigger dendritic cells (DCs) maturation and strengthen tumor immunity by inducing tumor ICD, illustrated by the release of damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), intracellular high-mobility group protein B1 (HMGB1) and cell-surface heat-shock proteins 70 kDa (HSP70) 42,43,44

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[1] The main metabolite of bromantane is 6-hydroxybromantane