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Based on the increased oxidative stress following MDMA exposure, we hypothesized that oxidative modifications of certain mitochondrial proteins lead to inhibition of their activities, resulting in mitochondrial dysfunction and ultimately contributing to MDMA-mediated organ damage

Flow cytometry was performed using a BD Fortessa instrument (BD) or NovoCyte Quanteon and data were analyzed using FlowJo v10.6.1 software (Tree Star)

BPC is a protein found naturally in the human digestive tract

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Experimental Interaction and Research Focus Interaction with intracellular signalling networks in controlled laboratory models Influence on transcriptional behaviour and gene expression pathways Modulation of enzymatic sensitivity and biochemical response mechanisms Impact on mitochondrial activity and cellular energy regulation Support of repeat-exposure and comparative pathway validation studies Laboratory Research Applications Cellular Repair and Regeneration Research: Examining cellular response behaviour and regenerative pathway modelling in vitro