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Altered functional connectivity between the amygdala and vmPFC neural circuit is also observed in rodents after traumatic events, leading to the pathophysiology of PTSD (Liang et al., 2014)

[50,51] Potential biologics have been generated to target pro-inflammatory cytokines, such as IL-1, interferon (IFN)-, IFN-, IL-6, TNF-, IL-17, and IL-21, and several clinical trials that aim at inhibiting the activities of these mediators have been initiated

L-glutathione is an endogenous tri-peptide consisting of the amino acids glutamic acid, cysteine and glycine

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This surplus of electron donors in the mitochondrial electron transport chain can overwhelm and impair mitochondrial complex I (Yan et al., 2016)