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doi:10.1071/RD14182 68 Behrouzi Lak, T., Hajshafiha, M., Nanbakhsh, F

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Symptoms of coronary artery disease can differ between men and women, but they usually include: Pain, tightness, pressure, or discomfort in the chest (angina) Shortness of breath Pain, weakness, numbness, or coldness in the arms or legs Pain in the jaw, throat, neck, back, or upper abdomen Extreme fatigue Nausea Peripheral Arterial Disease Peripheral arterial disease is a form of cardiovascular disease in which your limbs do not receive sufficient blood flow, often due to atherosclerosis

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Doberman pinschers with copper concentrations as low as 750 ppm may have morphologic evidence of hepatocellular damage and show improvement with copper chelation therapy.7 This supports the suggestion that the mechanism of copper accumulation may vary with different breeds