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-Tocopherol (30 mg/kg, i.p.) has shown beneficial effects in experimental renal ischemia, including reduction in tubular damage scores and cast formation, decreased blood urea nitrogen (BUN) and creatinine elevations, protection against oxidative DNA damage in renal tubular cells, and preservation of glomerular filtration capacity [53]

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This knowledge might be critically important for identifying patients who benefit most from the therapy with purified AAT protein and/or specific drugs with antioxidant potentials

2024;17(1): e310323215268