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Also removed from Category 2 in September 2024 and under PCAC review

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

These findings confirm its strong genetic safety profile under controlled laboratory conditions

Despite more than 500 published preclinical studies (primarily animal and cell-culture models from Sikiric and colleagues at the University of Zagreb), there have been essentially no registered human clinical trials for BPC-157 in the United States

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