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So there is plenty of evidence showing that Metformin and Vitamin B12 deficiency is a problem, especially with long term use of Metformin and this is a drug that is usually taken forever once it is prescribed Metformin And Vitamin B12 Deficiency The Solution The first thing to do is to get your vitamin B12 levels tested so that you have a baseline reading, dont follow the reference range but make sure your levels are over 400 as a minimum