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The good news is that B12 is one of the safest vitamins, but there are a few things to know about high-dose supplements and when theyre actually necessary

J Cell Physiol (2017) 232:177493

GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists