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It was also shown that cellular deletion of CARS2 caused a significant increase in the production of inflammatory cytokines in macrophages in response to lipopolysaccharide (LPS), a component of Gram-negative bacteria [81]

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Produces additive rather than redundant signaling

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If your experimental buffer system is highly alkaline, it's wise to add the Glutathione solution to your buffer immediately before use, rather than storing it in an alkaline solution where it will degrade more rapidly