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Its dramatic age-related decline is significant: plasma concentrations average 200 ng/mL at age 20 but typically plummet to 80 ng/mL by age 60a 60% reduction correlating with visible aging and reduced healing capacity

Hyperthyroidism increases risk of DVT, post-thrombotic syndrome, and pulmonary embolism, as well as the likelihood of arterial thromboembolism, in part by triggering atrial fibrillation and flutter

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Adrenal insufficiency When the adrenal glands do not produce enough cortisol and, occasionally, aldosterone, it is known as adrenal insufficiency (20)