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67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes

In addition to a kinetic response to changes in Cys concentration, the catalytic turnover of Cys by CDO leads to conversion of CDO to its mature (Cys-Tyr cofactor-containing) form that has a markedly increased catalytic efficiency (k cat /K m ) and longer catalytic half-life, as discussed earlier

Key benefits: Provides powerful antioxidant protection and detoxification

[0067] In some embodiments, the method comprises administering a composition comprising a mitophagy stimulant, wherein the mitophagy stimulant is urolithin A

Many patients describe the experience as feeling temporarily worse before gradual improvement begins