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This inhibition reduces the antioxidant capacity of cells, leading to an accumulation of ROS, causing further damage to cellular components and expediting cellular aging (Tan et al., 2020)

doi: 10.1159/000056191 142 KasemsukTVivithanapornPUnchernS

Physiol Genomics 16:2937 Vassilopoulos A et al (2014) SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress