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[DOI] [PMC free article] [PubMed] [Google Scholar] 156.Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, Chen L, Villemaire M, Ali Z, Jirik FR, et al

However, genomic studies using post-mortem or disease-affected tissues present inherent challenges, potentially obscuring cell-specific DNA methylation patterns

While epigenetic modifications are involved in carcinogenesis, these enzymes primarily participate in phase II conjugation and epigenetic regulation rather than the direct metabolic activation of procarcinogens

En cas de carence concomitante en folates , la supplmentation en vitamine B12 doit tre dbute en premier pour viter que celle en acide folique puise dans les dernires rserves de B12 (voir plus haut) et entrane une dgnrescence combine subaigu de la moelle

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