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In the presence of transition metals such as Fe 2+ or Cu 2+ , H 2 O 2 can participate in a sequence of reactions known as the Haber-Weiss and Fenton reactions, ultimately leading to the creation of OH- (Fenton, 1894)

Ferroptosis involves various metabolic processes, including iron, lipid and glutathione metabolism

For instance, ROS-mediated damage impairs the function of immune cells, reducing their ability to effectively combat infections while simultaneously promoting chronic inflammation ( 3.2 Immune cell dysfunction and the gut-kidney axis in CKD Immune cell dysfunction is a key driver of CKD progression (Figure 2), involving abnormalities in adaptive and innate immune cells, including T cells, B cells, and monocytes/macrophages

But AMPK can also influence body fat composition, and it plays a critical role in regulating your appetite