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Numerous studies have indicated that MDD is associated with gut dysbiosis, characterized by an increased prevalence of proinflammatory pathobionts, such as Enterobacteriaceae and Eggerthella , which may compromise gut wall integrity, as well as a diminished presence of anti-inflammatory probiotics, including Ruminococcus and Faecalibacterium , that enhance gut wall integrity [187,188,189,190]

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