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Data were extracted by two independent reviewers

A precision approach, baseline 25(OH)D assessment, IR/obesity stratification, and standardized dosing/duration should anchor future trials and practice

NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery

Abstract Background Fibromyalgia (FM) as a prototypical nociplastic pain condition displays a difficult therapeutic situation in many cases

Metabolism-based intervention is a simple, straightforward way to effectively increase membrane permeability and stimulate uptake of an antibacterial drug