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In accordance with NICE NG158, prompt diagnosis and treatment are critical to prevent pulmonary embolism (PE)

10.1016/j.isci.2023.10773037694143 311 Li P, Zhang L, Zhang M, et al

Remarkably, carnosine, a naturally occurring dipeptide composed of -alanine and L-histidine, was identified as a consistently downregulated metabolite in both models ( Mechanistically, our in vitro data revealed that carnosine not only suppressed LPS-induced cytokine production in BMDMs but also inhibited their polarization toward the M1-like pro-inflammatory phenotype, which is known to exacerbate lung tissue damage (Yan et al., 2024