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Tang et al, 2001)

showed only a 2.6-fold after the same period [17]

however, the majority of these studies were conducted on animal models, the hierarchy of evidence was low, and the results of different studies lacked consistency with each other

Studies in cell lines often use calcitriol, as cell lines such as A549 cells express low levels of 1-hydroxylase (CYP27B1), the enzyme responsible for vitamin D activation, and are unable to convert cholecalciferol to its active form [14]