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A 67 year old female is on the following medications: Aspirin 81 mg daily Lisinopril 5 mg daily Carafate 1 gm four times daily Omeprazole 40 mg daily Metformin 1000 mg twice daily Actos 15 mg daily Paroxetine 20 mg daily Valproic acid 250 mg twice daily Percocet 5/325 mg four times daily as needed Senna 2 tablets at bedtime B12 injection q month Amlodipine 5 mg daily Tylenol 1,000 mg three times daily The first thing that caught my eye was that this patient apparently has or had B12 deficiency with the monthly supplementation

This article is the first in a four-part series that reviews recent literature on cutaneous adverse reactions experienced with commonly prescribed biologic and targeted therapies, specifically tumor necrosis factor (TNF) alpha inhibitors, epidermal growth factor receptor (EGFR) inhibitors, small-molecule tyrosine kinase inhibitors (TKIs), and frequently used cell surface-targeted monoclonal antibodies

In CAG, mitochondrial phenylalanine and lysine were elevated, which suggested that their corresponding aminoacyl-tRNAs were blocked, which might lead to cessation of biological responses and mitochondrial dysfunction

The functions of taurine include the improvement of mitochondria-related diseases such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes and aging-related diseases 35