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It is possible that the function of Ecm38p was disrupted in an opt2 background

doi:10.1007/s00335-011-9387-6

Eygeris, Y., Gupta, M., Kim, J

proposed that thiamine supplementation may be indicated for all children with ASD (149), with the idea that heavy metal toxicity can hamper TKT activity, increase oxidative stress, and, in turn, disrupt thiamine homeostasis