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Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Functional analysis revealed common biological processes and pathways which may be modified in relation to ectopic cells, namely, cell adhesion and differentiation, hormone regulation/response, and developmental processes (Additional file 9)

Our study has important implications for our understanding of enzymatically active and inactive glutaredoxins and could be useful for the design and optimization of artificial glutaredoxins, glutaredoxin-coupled fluorescent redox sensors and transition-state inhibitors