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Briefly, HCT116 p53+/+ cells (4 10 4 per well) were coated in a 12-well plate

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At the same time, immune cells impose reciprocal metabolic constraints on cancer stem-like cells through oxidative stress, nutrient restriction, and inflammatory metabolites, which drive cancer stem-like cells plasticity, epithelial-to-mesenchymal transition (EMT)-like programs, and epigenetic remodeling

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