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doi:10.1016/j.esxm.2021.100377

Vitamin B12deficiency can manifest itself in the following clinical pictures: Hyperchromic macrocytic megaloblastic anemia (pernicious anemia, Biermer's anemia, Addison's anemia these are red blood cell maturation disorders) Funicular spinal disease [spinal cord damage] A vitamin B12deficiency confirmed by laboratory diagnostics can occur with: Years of malnutrition and malnutrition (e.g strictly vegetarian diet)

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The two compounds target different mechanisms and are frequently studied together in preclinical tissue repair research

This aligns with previous plasma metabolomics profiles observed in GWS, where dysregulation of energy metabolism was evident