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Sci Total Environ 692:441449

Comprising vast, densely packed networks of neurons and glial cells distributed throughout the intestinal wall, the ENS not only directly governs motility, secretion, and absorption but also engages in dynamic crosstalk with intestinal immune cells to establish immune defense barriers and fine-tune inflammatory responses

Systemic disruptors, such as those identified in Figure 2, with local cryotherapy to prevent injury and mitigate neurogenic inflammation, are important therapeutic targets

Complete blood count values, particularly hematocrit and hemoglobin, help ensure that testosterone increases have not pushed red blood cell production to problematic levels