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High levels of HEY2 recruit HDAC1 to the promoters of PGC-1 coactivator complex genes and carnitine palmitoyltransferase 1A/2 ( CPT1A/2 ) regulatory genes to mediate histone deacetylation and transcriptional repression, which results in decreased energy production, increased ROS levels, and cardiac dilation and failure

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In practical terms, the difference is small enough that standard dosing protocols do not adjust for it

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If you are due to have a series of injections, you will then be able to schedule your next appointment