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Activation of 3-AR via Gs cAMP PKA phosphorylation of hormone-sensitive lipase (HSL) leads to: Splitting of triglycerides into free fatty acids + glycerol Release of fatty acids from adipose tissue into the blood Increased oxidation of fatty acids in mitochondria (muscle, liver) Heffernan et al

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Interaction between the linker, pre-S1, and TRP domains determines folding, assembly, and trafficking of TRPV channels