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If you feel fine during and immediately after exercise, but you have a significant worsening of symptoms the next day, thats an indication that youre doing too much and need to back off a bit

(2008), a trial in 65 healthy elderly patients that spanned two years, reported the following side effects with MK-677 at 25mg/daily [17]: Increased appetite (67%) Joint pain (58%) Swelling in the lower extremities (44%) Muscle discomfort (33%) According to the study authors, these side effects were generally mild and tended to decrease after a few months into the trial