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4B0FXV2 4

H.et al (2015b)

Alternatively, the increased longevity could have resulted from decreased product-inhibition of the nematode homolog of cytoplasmic GPD1 by decreasing glycerol-3-phosphate levels, leading to increased flux through GPD1 to oxidize the cytoplasmic [NAD + ]/[NADH], a known prolongevity intervention ( 2 S-generating compound ergothioneine was shown to stimulate GPD1 and G3PS activity to extend longevity in C