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Salt-sensitive hypertension develops after short-term exposure to angiotensin II

It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

Neuropharmacology 76:2750 Ando K, Laborde Q, Lazar A, Godefroy D, Youssef I, Amar M, Pooler A, Potier M-C, Delatour B, Duyckaerts C (2014) Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D

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Rare mendelian primary immunodeficiency diseases associated with impaired NF-B signaling