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Beyond the impact of endothelial damage, peritubular capillary rarefaction, pericyte detachment, nephron loss, interstitial hypoxia, and persistent inflammation, metabolic disturbances in TECsparticularly defective FAO and lipid accumulationhave been identified as key contributors to EMT and the progression of renal fibrosis through maladaptive repair mechanisms (Miguel et al., 2021)

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Tamoxifen cytotoxic effect was demonstrated on prostate cancer, hepatocellular carcinoma [22] and astrocytoma [23]

Phase II detoxification is where the body takes reactive, dangerous intermediates created by Phase I and converts them into water-soluble molecules that can be excreted through bile, urine, and stool

In the auditory system, a previous study reported that a single nucleotide polymorphism in GPX1 might be associated with the vulnerability to noise-induced hearing loss (NIHL) among the Chinese Han population (Wen et al., 2014)