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Furthermore, a phenotypic analysis of immune cell profiles, using multiparametric flow cytometry, revealed higher proportions of activated T lymphocytes and non-classical monocytes (CD14 +/CD16 +) in the CSF of PD patients than controls (Schrder et al., 2018)

After removing 345 duplicate articles, the titles and abstracts of the remaining articles were reviewed, and 2908 articles were excluded, including reviews, animal studies, and non-randomized controlled trials (RCTs)

This leaves practitioners in a difficult position: acknowledging a promising safety signal while recognizing the profound limitations of unpublished data