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Animal models of Alzheimers disease: Applications, evaluation, and perspectives

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In conclusion, compared to normal cells, tumor cells exhibit a significantly higher ratio of de novo synthesized fatty acids, and this metabolic shift is positively correlated with tumor malignancy (62)

Interestingly, PD is also associated with iron overload and lipid peroxidation, which are highly consistent with ferroptosis, a form of regulated cell death that is initiated by iron-dependent phospholipid peroxidation (4)