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The primary consideration is that women using hormonal contraceptives may require dose adjustment, as exogenous estrogen can increase IGF-1 binding proteins and alter the free IGF-1 fraction measured in standard assays

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Perspective The primary analytic perspective was that of the Ministry of Health and Long-Term Care

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The transcriptomic data indicated that transcriptomic changes in mitochondrial genes were prominent features in the hippocampus of Hcy-treated rats, and defects in mitochondrial functions may specifically be involved