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This has earned MOTS-c a reputation as an exercise mimetic. For someone struggling with weight, especially if exercise is difficult, a peptide that signals the body to ramp up fat-burning and improve fitness is incredibly appealing

doi: 10.1371/journal.pone.0179538 76 StanleyTLChenCYBranchKLMakimuraHGrinspoonSK

The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

Morning fasted administration The most effective timing for AOD-9604 is morning administration in a fasted state