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According to Kaplan-Meier plots, patients with elevated levels of MMA had significantly increased cumulative incidence of cardiovascular and heart-specific death (Supplementary Fig

doi: 10.1016/S2666-5247(20)30144-0 249 SchwalfenbergG

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Apoptosis is induced via two main routes involving either the mitochondria (the intrinsic pathway) or the activation of death receptors (the extrinsic pathway)

After washing with PBS, the nuclei were counterstained with Hoechst 33342 (1:1000), and coverslips were mounted with Dako fluorescent mounting medium (S302380-2, Agilent Technologies)