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In line with impairments in B12 metabolism impacting mitochondrial morphology, humans and mice with genetic deficiency of MMUT have distorted mitochondria, including cristae with reduced matrix density and rarefication [54]

In addition to the cardiovascular system, Mn overexposure has also been linked to reproductive health effects

While these interventions are usually adjuncts to behavioral and educational therapies, understanding their roles, safety, and scientific basis can empower caregivers and clinicians to make informed decisions

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