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Anyone with known MTHFR mutations would benefit from the following: Check your supplements for added folic acid

Disruption of network synchrony and cognitive dysfunction after traumatic brain injury

Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/Ms into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

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First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events