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10.1016/j.tips.2009.10.004 Trends Pharmacol

approximately 2.42.8 at 1% concentration Primary function: Reconstitution solvent for lyophilised peptides with poor aqueous solubility at neutral pH Mechanism: Protonation of basic amino acid residues (Lys, Arg, His) increases net positive charge, improving aqueous solubilisation Best suited for: Peptides rich in hydrophobic residues, growth hormone-related peptides, IGF-1, IGF-2, GHRP-family peptides, and many neuropeptides Standard protocol: Reconstitute in acetic acid water first, then dilute to working concentration in physiological buffer or assay vehicle Format: Sterile, laboratory-grade solution supplied by Peptides Lab UK Storage: Store at room temperature or as directed

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doi: 10.1016/j.foodchem.2013.08.025 56 LiDWuM