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The combined quinone redox glutathione metabolism model can be used to simulate experimentally challenging scenarios such as potential redox cycling toxicity, while providing a platform from which quinone exposure and concentration toxicity experiments may be guided

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To further investigate the antiproliferative efficacy in vivo, three xenograft nude mouse models (DLD-1(KRAS G13D/- ), HT29(BRAF V600E ), and Caco-2-CR) were established

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