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Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Anti-TfR1 (136800), anti-iron sulfur cluster assembly scaffold protein (ISCU) (MA5-26595), anti-mitochondrial acyl carrier protein (mtACP) (PA5-30099), anti-GPX4 (MA5-32827), propidium iodide (PI) (11539226), anti-NDUFS1 (PA5-22309), Mitotracker Deep Red FM (M22426), anti-mouse Alexa Fluor 488 (MN1000), anti-rabbit Alexa Fluor 455 (437695), 4,6-diamino-2-phenylindole (DAPI) (D1306), bovine serum albumin (BSA) (BP9702), Hoechst 3342 (62249), and Bodipy 581/591 C11 (D3861) were purchased from Invitrogen/Molecular probes (Eugene, OR, USA)/ThermoFisher Scientific (Waltham, MA, USA)

Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory

TABLE 1 Current Drugs and Therapies in different stages of ALD

10.1016/j.freeradbiomed.2007.02.014